Senior Scientist - Therapeutic Modality Assessment for Surface Targets Job at Amgen, Thousand Oaks, CA

  • Amgen
  • Thousand Oaks, CA

Job Description

Amgen seeks a Senior Scientist to characterize cell-surface therapeutic targets and evaluate therapeutic modalities using quantitative experimental approaches. This early-stage validation role integrates proteomics and transcriptomics data to guide target prioritization and therapeutic strategy across disease areas.

Responsibilities

  • Propose and experimentally evaluate therapeutic modalities for surface targets based on target properties
  • Develop scalable, high-throughput quantitative workflows assessing protein degradation, internalization, trafficking, and cellular function
  • Integrate experimental findings into Go/No-Go decision packages guiding therapeutic modality selection
  • Collaborate across early validation team and functions to document workflows and present validated data

Requirements

  • Ph.D. in Cell Biology, Biomedical Science, Immunology, Oncology, Pharmacology, or related field; or Master's plus 2 years relevant experience; or Bachelor's plus 4 years relevant experience
  • 2+ years biotechnology or pharmaceutical industry research experience
  • Demonstrated contributions to discovery programs across multiple therapeutic modalities
  • Experience with early target validation, antibody/binder, or small-molecule characterization
  • Hands-on proficiency with flow cytometry or quantitative imaging for surface target measurement
  • Experience developing and executing high-throughput cell-based screening assays
  • Strong data analysis, problem-solving, and scientific communication skills

Job Tags

Similar Jobs

KinderCare

Elementary and Middle School Teacher Job at KinderCare

KinderCare is seeking a dedicated Teacher for Heights Terrace Elementary and Middle School. In this role, you will design and deliver engaging, developmentally appropriate instruction that supports academic and social-emotional growth for diverse learners. You will create... 

Living Spaces

Warehouse Associate - PM- (Furniture Assembler) Job at Living Spaces

 ...drills, and screw drivers Unload trailers by hand Move furniture with dollies and pallet jacks Ensure outbound picked furniture...  ...monitors and ensures that outbound furniture is properly assembled Use proper lifting techniques: lift, push, stooping twisting... 

Uncommon Schools

Middle School ELA Teacher Job at Uncommon Schools

 ...Company Description Uncommon Schools is a nonprofit network of high-performing public charter schools dedicated...  ...difference! Job Description Uncommon Middle School English Language Arts (ELA) teachers are passionate about literature and building an engaging... 

SOFITEL

Guest Service Agent/Front Desk Job at SOFITEL

Job Description Job Description Company Description "Why work for Accor? We are far more than a worldwide leader. We welcome you as you are and you can find a job and brand that matches your personality. We support you to grow and learn every day, making sure...

LINCOLN COMMUNITY HOSPITAL AND NURSING HOME

Housekeeper- Byers Clinic Job at LINCOLN COMMUNITY HOSPITAL AND NURSING HOME

 ...PURPOSE:The Housekeeper is responsible for maintaining a clean, sanitary, and safe environment throughout the Critical Access Hospital. This role supports infection prevention, patient safety, and regulatory compliance by performing routine and specialized cleaning of...